Endocrine Abstracts

Aim: To evaluate adiponectin and resistin levels and their relationship with various biochemical and metabolic and atherogenic parameters markers, as well as their correlation, and to investigate its contribution in pathogenesis of insulin resistance in cohort women with PCOS and of insulin resistance as well as in non-insulin resistant women with PCOS. Methods: This study was designed as a cross-sectional and involves 80 premenopausal women. Of these patients, 63 females have...

Hypoparathyroidism is, in Italy, an orphan disease because the hormonal replacement therapy is possible only with teriparatide (fragment 1–34 of of human parathyroid hormone). Otherwise the patients use oral calcium and calcitriol. This scheme of therapy obtained correct plasmatic calcium and phosphate levels, correct urinary excretion of calcium and phosphate, adequate quality of life – QoL only in a little percentage of patients. Especially kidney stones, intra-ren...

Aim: To find if testosterone undecanoat 1000 mg injection (Nebido; Bayer-Schering) has a negative effect on prostate.Materials and methods: i) PSA (ng/ml) was registred retrospective (from files) and prospective analysis (onset 2010). ii) From over 175 patients to whom testosterone undecanoate 1000 mg, i.m. was administrated at 3 months, in the last 4 years, and to whom the prostatic volume was quantified (Journal of Sexual Medicine8</st...

Objectives: The study of the real indications for thyroid ultrasound and in which pathological conditions the echography is of real use and not for abuse.Material and methods: In the last 10 years, over 13 000 echographies were performed in 5136 consecutive patients for ‘thyroid disturbances’. In a previous paper we described 7 echographic patterns for thyroid ultrasound (9th ECE). The diagnosis of Hashimoto’s thyroiditis (HT) was consider...

Background: Clinical features of acromegaly develop insidiously and the diagnosis is often delayed. However, diagnostic delay (DD) in acromegaly has not been systematically investigated. Our primary aim was to investigate DD in a nationwide cohort of patients with acromegaly. Secondary aim was to study the impact of DD on morbidity and mortality.Methods: Adult patients diagnosed with acromegaly between 2001 and 2013 were identified in the Swedish Nationa...

Tc-99m sestamibi (MIBI) imaging is able to localize parathyroid adenomas/carcinomas in patients with primary hyperparathyroidism. Brown tumours are one of the skeletal manifestations of long standing hyperparathyroidism and its incidence has been reported to be 3%. Radiological features of these tumors may mimic bone metastasis. There are only a few reports showing brown tumours uptake in the whole-body Tc-sestamibi scan.We report a 72-year-old female wi...

Obesity epidemic is one of the major concerns in the world. Worryingly, a high percentage of pregnant women have obesity, which could imply several consequences. Maternal obesity leads to different abnormalities in pregnancy and delivery. In addition, recent studies show that the offspring of obese mothers has an increased probability to suffer cardiovascular, metabolic and reproductive diseases. We have previously demonstrated that exposure to a high fat diet is related to ob...

Multiple aspects of physiology and pathophysiology, including endocrine function, are influenced by endogenous circadian timing mechanisms. In mammals, cell autonomous clocks are present in all major tissues throughout the body. These clocks are synchronised via complex signalling pathways and are believed to drive local aspects of physiology.Recently published data have revealed 24-h rhythms in up to 20% of the adipose transcriptome, suggesting profound...

X-linked hypophosphatemic rickets (XLH) is associated with mutations in PHEX, upregulation of FGF23, leading to hypophosphatemia, abnormal bone development and short stature. H-MAB to FGF23, Burosumab, is the new therapy for XLH. Among PHEX mutations, c.1586+6T >C, partially destroying the splice-site, is presumably associated to a mild phenotype not described so far. We describe two siblings bearing the PHEX c.1586+6T >C variant. Cas...

Type 2 diabetes (T2DM) is a chronic and progressive disease associated with microvascular and macrovascular complications leading to increased morbidity and mortality. Insulin remains the cornerstone therapy for longer-duration T2DM and b-cell failure. Glucagon-like peptide-1 receptor agonists are a class of multifactorial T2DM medications that have been shown to improve numerous risk factors for diabetes-related complications, including glycemic control, reduction in body wei...